Shubo Du

Personal Profile

Du Shubo, Associate Professor and Master's Supervisor. He obtained his Ph.D. in Science from the National University of Singapore in 2019, followed by postdoctoral research at the Department of Chemistry, National University of Singapore. He joined Dalian University of Technology in 2022. His research focuses on biomolecular targeted controlled release, addressing key scientific challenges in novel vaccine and antibody drug development, cancer cell detection and therapy. He has conducted studies on intracellular delivery of antibody drugs, tumor suppression mechanisms, and exploration of tumor cell proteomics, yielding a series of innovative publications. His research outcomes have been published in 20 SCI-indexed papers, appearing in prestigious international journals such as ACS Central Science, Journal of the American Chemical Society, and Angewandte Chemie International Edition.

Representative Achievements

• Zhang, B., Brahma, K. R., Zhu, L., Feng, J., Hu, S., Qian, L., Du, S.*; Yao, S. Q.*, Ge, J.*, Insulin-like Growth Factor 2 (IGF2)-Fused Lysosomal Targeting Chimeras for Degradation of Extracellular and Membrane Proteins. J. Am. Chem. Soc. 2023, 145, 24272-24283.
• Qian, L.*; Lin, X.; Gao, X.; Khan, R. U.; Liao, J.-Y.; Du, S.*; Ge, J.; Zeng, S.; Yao, S. Q.*, The Dawn of a New Era: Targeting the “Undruggables” with Antibody-Based Therapeutics. Chemical Reviews 2023, 123, 7782-7853.
• Du, W.#; Du, S.#; Dong, X.#; Bai, H.; Jiang, J.; Hao, S.; Yang, F.; Xiao, Q.; Zhang, B.; Ge, J.; Gao, L.; Li, L.*; Yao, S. Q.*; Huang, W.*, Biodegradable silica nanocapsules enable efficient nuclear-targeted delivery of native proteins for cancer therapy. Biomaterials 2023, 294, 122000. (#Co-first author)
• Ge, J.; Du, S.*; Yao, S. Q.*, Bifunctional Lipid-Derived Affinity-Based Probes (AfBPs) for Analysis of Lipid–Protein Interactome. Accounts of Chemical Research 2022, 55 (24), 3663-3674.
• Xie, Y.#; Du, S.#; Liu, Z.; Liu, M.; Xu, Z.; Wang, X.; Kee, J. X.; Yi, F.*; Sun, H.*; Yao, S. Q.*, Chemical Biology Tools for Protein Lysine Acylation. Angew. Chem. Int. Ed. 2022.04, 61 (21), e202200303. (#Co-first author)
• Du, S.; Liew, S. S.; Zhang, C-w.; Du, W.; Lang, W.; Yao, C. Y.; Li, L.; Ge, J.*; Yao, S. Q.*, Cell-Permeant Bioadaptors for Cytosolic Delivery of Native Antibodies: A “Mix-and-Go” Approach. ACS Cent. Sci. 2020.12, 6 (12), 2362–2376.
• Qu, Y.; Zhan, Q.; Du, S.*; Ding, Y.; Fang, B.; Du, W.; Wu, Q.*; Yu, H.; Li, L.*; Huang, W., Catalysis-based specific detection and inhibition of tyrosinase and their application. J. Pharm. Anal. 2020.10, 10 (5), 414-425.
• Du, S.; Liew, S. S.; Li, L.; Yao, S. Q.*, Bypassing endocytosis: direct cytosolic delivery of proteins. J. Am. Chem. Soc. 2018.11, 140 (47), 15986-15996.
• Du, S.; Wang, D.; Lee, J.-S.; Peng, B.; Ge, J.*; Yao, S. Q.*, Cell type-selective imaging and profiling of newly synthesized proteomes by using puromycin analogues. Chem. Commun. 2017.08, 53 (60), 8443-8446.