Jiaqi Lin

Biography

Lin Jiaqi, Professor at the School of Biological Engineering, Dalian University of Technology, is a core member of the Ministry of Education Key Laboratory of Intelligent Biomanufacturing and a recipient of the National Youth Talent Award (Outstanding Young Talent Program by the Organization Department of the CPC Central Committee). He obtained his Bachelor's degree from Beihang University in 2005 and his Ph.D. in Biomedical Engineering (Nano-Bio Interfaces) from Dalian University of Technology in 2012. From 2012 to 2018, he conducted postdoctoral research at the Massachusetts Institute of Technology (nucleic acid therapeutics). From 2018 to 2020, he served as Director of Research and Development at BrainCo Inc. in the United States. He has been honored as a Young Scientist by the Ministry of Science and Technology, a Ningbo Yongjiang Talent, and a Dalian Overseas High-Level Talent. His research focuses on mRNA therapeutics and vaccines, nanobiological interfaces, tissue engineering and regeneration, and brain-computer interfaces. Publications Published in international journals including Nature Biomedical Engineering, Nature Communications, Advanced Materials, Nano Letters, Science Advances, and Small. Authored 2 ESI highly cited papers with over 3,300 citations and an h-index of 19. Research significance garnered widespread recognition from peers globally, featured in reviews and positive coverage by Chemical Reviews, Chemical Society Reviews, Accounts of Chemical Research, Nature Reviews Drug Discovery, and Science Daily. As principal investigator, he has secured multiple grants including the Ministry of Science and Technology's Key R&D Program for Young Scientists, provincial joint science and technology projects, municipal Science and Technology Innovation Commission's “Challenge-Based Project,” and municipal key R&D initiatives, totaling 18 million yuan in government funding. He has filed over 20 invention patents in related fields, with 12 published applications and 5 granted patents, three of which have been successfully commercialized.

Representative Achievements

• 1. Yufeng Zhang, Liuwei Zhang, Hui Gao, Shubo Du, Qixian Chen, Xueguang Lu*, Jiaqi Lin*. Multi-functional lipid nanoformulations for enhancing the efficacy of mRNA tumor vaccines by reversing tumor immunosuppressive microenvironment. Nano Today, 2025, 63, 102757
• 2. Bangda Fan, Sujia Liu, Yinghuan Xu, Xinghuan Ma, Wenbin Qi, Lei Miao, Lin Liu, Shubo Du, Jiaqi Lin*. Mechanistic insights into circularization via Anabaena group I intron-based scarless circular RNA. Molecular Therapy Nucleic Acids, 2025, 36: 102626
• 3. Dongyang Wang+, Hailing Xue+, et. al, Fengyu Cong, Yanhua Li*, Fei Song* and Jiaqi Lin*. A tough semi-dry hydrogel electrode with anti-bacterial properties for long-term repeatable non-invasive EEG acquisition. Microsystems & Nanoengineering, 2025, 11, 105
• 4. Runying Wang+, Yufeng Zhang+, Shubo Du, Yanhua Li, Yanying Ren* and Jiaqi Lin*. Nanoformulations Downregulating METTL16 Combined with mRNA Tumor Vaccines Suppress Triple-Negative Breast Cancer and Prevent Metastasis. International Journal of Nanomedicine, 2025, 20, 8951–8966
• 5. Linfeng Wang+, Sujia Liu+, et. al, Bingwei Wang*, Jiaqi Lin*, Ji Zeng*. Machine learning -based analysis of the impact of 5' untranslated region on protein expression. Nucleic Acid Research, 2025, 53 , gkaf861
• 6. Xinghuan Ma, Sujia Liu, Bangda Fan, Danni Jin, Lei Miao, Lin Liu, Shubo Du*, Jiaqi Lin*. Enhancing mRNA Translation Efficiency by Introducing Sequence- Optimized AU-Rich Elements in 3’UTR via HuR Anchorage. Molecular Therapy Nucleic Acids, 2025, 36: 102485
• 7. ingjiao Li, Jie Hu, Danni Jin, Haonan Huo, Ning Chen*, Jiaqi Lin*, Xueguang Lu*. High‑throughput synthesis and optimization of ionizable lipids through A3 coupling for efficient mRNA delivery. Journal of Nanobiotechnology, 2024, 22:672
• 8. Xingdi Cheng+, Sujia Liu+, Jing Sun, et. al, Xiaolan Cui*, Jiaqi Lin*, Xueguang Lu*, A Synergistic Lipid Nanoparticle Encapsulating mRNA Shingles Vaccine Induces Potent Immune Responses and Protects Guinea Pigs from Viral Challenges. Advanced Materials, 2023, 25, e2310886
• 9. Lei Miao+, Jiaqi Lin(co-first)+, Yuxuan Huang, Linxian Li, Derfogail Delcassian, Yifan Ge, Yunhua Shi, Daniel G. Anderson. Synergistic Lipid Compositions for Albumin Receptor Mediated Delivery of mRNA to the Liver. Nature communications. 2020, 11, 2424
• 10. Jiaqi Lin, Alfredo Alexander-Katz. Cell Membranes Open "Doors" for Cationic Nanoparticles/Biomolecules: Insights into Uptake Kinetics. ACS Nano, 2013, 7, 10799-10808.